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| Advance in the main components, physiological activities and detection technology of 4, 4-dimethylsterols in vegetable oils |
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Received:August 13, 2025 Revised:April 01, 2026 Accepted:October 28, 2025
Published：
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| DOI：10.19902/j.cnki.zgyz.1003-7969.250368 |
| KeyWord:4, 4-dimethylsterols physiological activity detection technology vegetable oil |
| FundProject:湖南省市场监督管理局项目（2024KJJH11） |
| Author Name | Affiliation | | SHANGGUAN Jia1， TIAN Xiaodong2， LI Zheng1， CHEN Tongqiang1，
LIANG Jun3, WU Haizhi1， LI Fei4 | 1.Hunan Provincial Institute of Product and Goods Quality Inspection, Changsha 410007, China
2.Hunan
Shanrun Camellia Oil Technology Development Co. , Ltd. ,Yueyang 414000, Hunan, China
3.GRG
Metrology and Test (Hunan) Co. , Ltd. , Changsha 410006, China
4.Yuanling County Market
Supervision and Administration Bureau, Huaihua 418000, Hunan, China |
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| Abstract: |
| 4,4-Dimethylsterol, as a type of phytosterol with a unique chemical structure, possesses various physiological activities. To provide a reference for the accurate quantification and functional application of 4,4-dimethylsterols in vegetable oils, the main components, physiological activities, and detection methods of 4,4-dimethylsterols were reviewed, and its future research directions were prospected. The core components of 4,4-dimethylsterols include cycloartenol, 24-methylene-cycloartanol, cycloartanol, lupeol, α-amyrin, and β-amyrin, etc. These components are widely present in vegetable oils such as rice bran oil and groundcherry seed oil. 4,4-Dimethylsterols have anti-inflammatory, hypoglycemic, hypolipidemic, hypocholesterolemic, anti-cancer, anti-Alzheimer′s disease (AD), and anti-Parkinson′s disease (PD) effects. Currently, the conventional detection methods for 4,4-dimethylsterols in vegetable oils mainly include spectroscopy (spectrophotometry), chromatography, and chromatography-mass spectrometry combined techniques. Among them, gas chromatography-mass spectrometry is the most widely used and highly promising detection method due to its advantages such as strong anti-interference ability, fast analysis speed, and environmental friendliness, and is applicable for the detection of complex matrix samples (such as vegetable oils). In the future, efforts should be focused on establishing a standardized detection system, improving the clinical verification system, and deeply analyzing the structure-function relationship to promote the precise detection and efficient utilization of 4,4-dimethylsterols, providing scientific support for the quality evaluation of vegetable oils, the development of functional foods, and drug research. |
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