| 刘玲馨，王阳，朱毅.高脂饮食造成认知功能损伤的机制探索[J].中国油脂,2025,50(7):.[LIU Lingxin，WANG Yang，ZHU Yi.Mechanism exploration of cognitive impairment caused by high fat diet[J].China Oils and Fats,2025,50(7):.] |
| 高脂饮食造成认知功能损伤的机制探索 |
| Mechanism exploration of cognitive impairment caused by high fat diet |
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| DOI：10.19902/j.cnki.zgyz.1003-7969.240109 |
| 中文关键词: 高脂饮食 认知障碍 机制探索 |
| 英文关键词:high fat diet cognitive impairment mechanism exploration |
| 基金项目:国家自然科学基金项目(31101263) |
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| 摘要点击次数: 94 |
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| 中文摘要: |
| 长期的高脂饮食（HFD）会造成大脑能量代谢紊乱，引发认知障碍，影响大脑功能。旨在为膳食营养或临床手段改善HFD介导的认知功能障碍提供理论基础,系统梳理了HFD造成认知功能损伤的机制。HFD通过神经炎症、氧化应激、线粒体功能障碍、胰岛素抵抗、血脑屏障受损、表观遗传紊乱和破坏突触可塑性等途径的单一或复合作用，造成大脑认知功能受损或下降。未来研究应进一步探索大脑代谢性损伤的确切机制，并通过研究提供预防或治疗HFD造成的认知功能障碍的有效手段。 |
| 英文摘要: |
| Long-term high fat diet (HFD) causes energy metabolism disorders in the brain, triggering cognitive impairment and affecting brain function. Aiming to provide a theoretical basis for improving HFD-mediated cognitive dysfunction through dietary nutrition or clinical interventions, the mechanisms causing cognitive impairment by HFD were systematically reviewed. HFD causes impaired or decreased cognitive function in the brain through single or compounded effects of neuroinflammation, oxidative stress, mitochondrial dysfunction, insulin resistance, impaired blood-brain barrier, epigenetic disorders, and disrupting synaptic plasticity. Future research should further explore the precise mechanisms of metabolic brain injuries and provide effective means for preventing or treating cognitive dysfunction caused by HFD through research. |
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