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| Preventive effect of flaxseed oil against diabetic retinopathy in obese mice |
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| DOI： |
| KeyWord:flaxseed oil diabetic retinopathy obese |
| FundProject:陕西省自然科学基础研究计划项目（2017JM8060）；陕西省教育厅专项科研计划项目（19JK0772）；西安医学院2018年配套基金项目（2018PT60）；省级、校级大学生创新创业训练计划项目（S201911840002，2018DC-62） |
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| Abstract: |
| The preventive effect of flaxseed oil against diabetic retinopathy in obese mice was studied. KM mice were randomly divided into normal dietary group (standard mice grain), high-fat diet group (high lard mice grain). After feeding for eight weeks, the weight and insulin resistance were examined respectively to analyze the induced condition of obesity diabetes. The obese mice were further divided into two groups: the high-fat diet group (lard) and the flaxseed oil group (lard+flaxseed oil). After eight weeks of simultaneous feeding with the normal diet group, the weight and insulin resistance of three groups of mice were examined respectively. The mice were executed, the retina tissue was taken, and the levels of retinal inflammatory factor IL-10 and retinal vascular endothelial growth factor VEGF were detected by ELISA. The results showed that after eight weeks of continuous feeding, mice in the high-fat diet group showed significant obesity, insulin resistance symptoms, and the obese diabetic mice model was successfully introduced, and after eight weeks of feeding, compared with high-fat diet group, the obesity status of mice in the flaxseed oil group did not improve (P＞0.05), but the insulin resistance was significantly improved(P＜0.05), the levels of IL-10 and VEGF were significantly reduced (P＜0.05). The results indicated that dietary feeding with flaxseed oil could improve retinal damage in obese mice caused by high-fat diet. |
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