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| Process optimization of preparation of 10 fatty acid ethanolamines and its structural characterization |
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| DOI： |
| KeyWord:fatty acid ethanolamine preparation structural characterization |
| FundProject: |
| Author Name | Affiliation | | LI Mengyu1,2, CHEN Weizhu2,3, JIN Wenhui2,3, FANG Hua2,3, HONG Zhuan2,3, ZHANG Yucang1 | 1.College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China
2.Technical Innovation Center for Utilization of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, Fujian, China
3.Collaborative Innovation Center for Marine Biotechnology, Higher Vocational College, Fujian Province, Xiamen 361005, Fujian, China |
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| Abstract: |
| In order to optimize the process of preparation of fatty acid ethanolamine, with methyl oleate and ethanolamine as raw materials, n-oleoyl ethanolamine was prepared by solvent free method, and the reaction conditions were optimized by single factor experiment. Then 10 fatty acid methyl esters were used as raw materials, the universality of the method was investigated, and the structures of 10 fatty acid ethanolamines were characterized. The results showed that the optimal process conditions of preparation of n-oleoyl ethanolamine were obtained as follows:solvent free, molar ratio of methyl oleate to ethanolamine 1∶5, reaction temperature 100℃ and reaction time 15 h. Under these conditions, the yield of n-oleoyl ethanolamine was 76.52%. Under the optimal conditions, the universality of the substrate was investigated, and the yields of the 10 fatty acid ethanolamines(target compounds) were 53%-87%. The structures of the target compounds were further confirmed by 1H NMR, 13C NMR and high resolution mass spectrometry. The method has the advantages of no pollution, low cost, simple operation, and can obtain high-purity fatty acid ethanolamine above gram level, which can provide sufficient samples for the biological activity research of fatty acid ethanolamine in the future. |
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